Boster Bio Anti-Topoisomerase (DNA) I, Mitochondrial (TOP1MT) Monoclonal Antibody catalog # M09702. Tested in IHC applications. This antibody reacts with Human. Supplied as 100ug/vial in Liquid form antibody.

ENA omfattar bland annat antigenerna Sm, RNP, SS-A (=Ro), SS-B (=La), Scl-70 (topoisomeras 1) och Jo-1 (histidyl tRNA-syntetas). ANA har en hög sensitivitet

85 % av patienter med systemisk skleros med positiv anti-topoisomeras anti- kroppar (anti-Scl 70) utvecklar ILD och antikroppens titer är korrelerad med. SCO-101 in combination with an anti-cancer agent for the treatment of cancer. Specific combination therapies include: SCO-101 + specific topoisomerase I Tillsätt 1 μg av anti-immunglobulin G (IgG), anti-histon H3 (som en ng super plasmid pSupFG1 DNA helt med ett pl Vaccinia Topoisomeras I Topoisomeras och helikas: Öppnar upp dubbelhelixen. ”Single strand binding proteins”: Binder till enkelsträngat DNA som temporärt bildas och skyddar det från Scl-70-antigenen har identifierats som ett cellformigt enzym, DNA topoisomeras I (30). Antikroppar mot Scl-70 har rapporterats hos upp till 56 procent av Topoisomeras 1: Scl-70. MHCII. CITR.

They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Use Anti-Topoisomerase II Antibody, clone SWT3D1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Topoisomerase II also known as DNA topoisomerase 2-alpha. Target description ~175 kDa observed. Uniprot describes 4 isoforms ranging from 174 … Objective: Anti-topoisomerase I (anti-topo I) autoantibodies in systemic sclerosis (SSc) are associated with diffuse skin involvement and interstitial lung fibrosis. Thus far, however, the relationship between anti-topo I antibody response and disease course has not yet been fully evaluated. Listed below are anti-Topoisomerase II antibodies from multiple suppliers. Topoisomerase II is a reported alias name for the human gene TOP2A, or 'DNA topoisomerase II alpha'.

"Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya epitope-specific antibodies against the tumor-related antigen topoisomerase IIa

Topoisomerase II is a reported alias name for the human gene TOP2A, or 'DNA topoisomerase II alpha'. The 1531-amino acid protein is a member of the Type II topoisomerase family.

Response to Anti-Topoisomerase II Agents Ian G. Cowell * and Caroline A. Austin Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE2 4HH, UK; E-Mail: caroline.austin@ncl.ac.uk * Author to whom correspondence should be addressed; E-Mail: ian.cowell@ncl.ac.uk;

The anti-tumour activity of topotecan involves the inhibition of topoisomerase-I, an enzyme intimately involved in DNA replication as it relieves the torsional strain Anti-dsDNA-antikroppar är en markör för systemisk lupus erythematosus (SLE) och Scl70 (DNA-topoisomeras I). Sklerodermi.

- Improved sensitivity and specificity. - Long-term security of supply. - Animal-free production. For more information see here. anti-Topoisomerase I antibody, anti-TOP1 antibody, anti-DNA topoisomerase 1 antibody, anti-DNA topoisomerase I antibody, anti-EC 5.99.1.2 antibody, anti-TOPI antibody, anti-topoisomerase (DNA) I antibody, anti-type I DNA topoisomerase antibody Anti-topoisomerase antibodies (ATA) are directed against topoisomerase and found in several diseases, most importantly scleroderma.Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Use Anti-Topoisomerase II Antibody, clone SWT3D1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Topoisomerase II also known as DNA topoisomerase 2-alpha. Target description ~175 kDa observed.
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English.

Topoisomerases are ubiquitous enzymes necessary for controlling the interlinking and twisting of DNA molecules. Among the four topoisomerases identified in eubacteria, two, DNA gyrase and topoisomerase IV, have been exploited by nature and the pharmaceutical industry as antibacterial targets. Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A is an antibody against Topoisomerase I-DNA Covalent Complexes for use in Immunocytochemistry, Flow Cytometry, Dot Blot, ELISA.
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1998-08-01

Topoisomerase I Antibodies This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. All lanes : Anti-Topoisomerase II beta/TOP2B antibody (ab72334) at 0.04 µg/ml Lane 1 : Whole cell lysate from Hela cells at 50 µg Lane 2 : Whole cell lysate from Hela cells at 15 µg Lane 3 : Whole cell lysate from Hela cells at 5 µg Lane 4 : Whole cell lysate from 293T cells at 50 µg Developed using the ECL technique. Predicted band size DNA topoisomerase I is an enzyme responsible for the relaxation of coiled DNA. Anti-topoisomerase I antibodies (also called anti-Scl-70 antibodies) are directed against different epitopes on this enzyme (Simon et al., 2009). Ontology: Topoisomerase-1 antibody (C0700437) Derived from the NIH UMLS (Unified Medical Language System) All lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human acute T cell leukemia) whole cell lysate Lane 3 : Neuro-2a (mouse neuroblastoma) whole cell lysate Lane 4 : Human breast cancer lysate Lane 5 : Mouse thymus lysate The presence of anti-SCL-70 (anti-topoisomerase) antibodies is highly specific to the diagnosis of diffuse scleroderma, while the presence of anti-centromere antibodies is highly specific to the diagnosis of limited scleroderma.

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Ontology: Topoisomerase-1 antibody (C0700437) Derived from the NIH UMLS (Unified Medical Language System)

Anti-Mülleriskt Hormon (AMH) kan eventuellt Antikropparna binder till PD-1, utan att inaktivera CD8-cellen, vilket möjliggör dess immunologiska funktion och förstörelse av tumörcellen. Patienter vars av J Wastesson · Citerat av 1 — mykobakteriers anti- biotikakänslighet i vilken författarna visar att tillägg av en monoklonal anti- genom vilken topoisomeras-I-hämmare aktiverar genen är which is is a chemotherapeutic agent that is a topoisomerase inhibitor. Konferenser. Herben, V., et al.: Anti-Cancer Drugs, 9, 411 (1998), Hsiang, Y., et al.

Acheter Anti-Topoisomerase II alpha Anticorps [ABT-TOPO] [ABT-TOPO] (A94715). Applications: IHC and WB. Réactivité: Human. ️ Livraison gratuite

Thus far, however, the relations between the ATA response and disease course have not yet been fully evaluated. Objectives Historically, systemic scleroderma was diagnosed as either diffuse or limited. The presence of anti-SCL-70 (anti-topoisomerase) antibodies is highly specific to the diagnosis of diffuse scleroderma, while the presence of anti-centromere antibodies is highly specific to the diagnosis of limited scleroderma. The presence of Scl-70 antibodies (also referred to as topoisomerase I, topo-I or ATA) is considered diagnostic for systemic sclerosis (SSc). Scl-70 antibodies alone are detected in about 20 percent of SSc patients and are associated with the diffuse form of the disease, which may include specific organ involvement and poor prognosis.

The 1531-amino acid protein is a member of the Type II topoisomerase family. The cellular localization is predicted to be cytoplasmic and nuclear. A nice clip i found on the mechanisms of action of topoisomerase 1 and 2 Anti-topoisomerase antibodies (ATA) are directed against topoisomerase and found in several diseases, most importantly scleroderma. Diseases with ATA are autoimmune disease because they react with self-proteins. They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Use Anti-Topoisomerase II Antibody, clone SWT3D1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Topoisomerase II also known as DNA topoisomerase 2-alpha. Target description ~175 kDa observed.